Angiotensin Receptor
Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.
Angiotensin Receptor Isoform Specific Products
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Angiotensin Receptor Inhibitors
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Angiotensin Receptor Agonists
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Angiotensin Receptor Antagonists
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Angiotensin Receptor Activators
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Angiotensin Receptor Modulators
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Angiotensin Receptor Chemicals
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Angiotensin Receptor Ligands
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Angiotensin Receptor Related Products (300)
Related Products (300)
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Antibodies (7)
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Angiotensin Receptor Isoform Comparison
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Angiotensin II (1-4), human TFA
0 ImagesCat. No.: HY-P1792AAngiotensin II (1-4), human (TFA) is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney.
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EXP-408
0 ImagesCat. No.: HY-114281CAS No.: 169203-73-0EXP-408 is a compound that can inhibit the formation and action of angiotensin II. EXP-408 can be used for the research of cardiovascular disease, such as hypertension.
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Novokinin TFA
0 ImagesCat. No.: HY-P0080ACAS No.: 1262750-59-3Novokinin TFA is a peptide agonist of the angiotensin AT2 receptor.
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BMS-248360
0 ImagesCat. No.: HY-114953CAS No.: 254737-87-6BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor, with Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 displays hypertensive effects.
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Eprosartan mesylate (Standard)
0 ImagesCat. No.: HY-15834ARCAS No.: 144143-96-4Synonyms: SKF-108566J (Standard)Eprosartan (mesylate) (Standard) is the analytical standard of Eprosartan (mesylate). This product is intended for research and analytical applications. Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan mesylate binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively.
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BPP 5a
0 ImagesCat. No.: HY-P2619CAS No.: 30505-63-6BPP 5a is a bradykinin-potentiating peptide with vasorelaxant activity, which is found in Bothrops jararaca venom. BPP 5a is an angiotensin-converting enzyme (ACE) inhibitor with a Ki value of 400 nM. BPP 5a is promising for research of hypertension and cardiovascular diseases.
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Imarikiren hydrochloride
0 ImagesCat. No.: HY-109034ACAS No.: 1202269-24-6Synonyms: AK-272; SCO-272Imarikiren hydrochloride (AK-272) is an orally active, selective Renin inhibitor with an IC50 value of 2.1 nM against h-Renin. Imarikiren hydrochloride blocks the conversion of Angiotensinogen to Angiotensin I and reduces mean arterial pressure by inhibiting Angiotensin II that binds to AT1. Imarikiren hydrochloride alleviates myocardial hypertrophy and pulmonary congestion, exerting cardioprotective effects. Imarikiren hydrochloride can be used in research related to hypertension and heart failure.
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Pomisartan
0 ImagesCat. No.: HY-106123CAS No.: 144702-17-0Pomisartan is an orally active angiotensin II receptor type AT1 antagonist (IC50=0.26 μM). Pomisartan works by inhibiting the binding of angiotensin II to the AT1 receptor, thereby blocking the vasoconstriction and aldosterone release caused by this interaction. Pomisartan results in a blood pressure-lowering effect.
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DMP 811
0 ImagesCat. No.: HY-180401CAS No.: 139964-19-5DMP 811 is a potent, orally active and selective angiotensin II subtype receptor AT1 antagonist. DMP 811 exhibits selectivity for AT1 (IC50 = 6 nM) over AT2 (IC50 >10 μM). DMP 811 exhibits potent antihypertensive activity in rats and dogs. DMP 811 can be used for the research of hypertension.
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KRH-594
0 ImagesCat. No.: HY-19253ACAS No.: 167006-13-5KRH-594 is an orally active angiotensin AT1 receptor antagonist. KRH-594 ameliorates the progression of diabetic nephropathy and hyperlipidaemia. KRH-594 inhibits cardiac hypertrophy.
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Angiotensin II antipeptide
0 ImagesCat. No.: HY-W140282CAS No.: 121379-63-3
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Losartan-d2
0 ImagesCat. No.: HY-17512S3CAS No.: 1030936-22-1Synonyms: DuP-753-d2Losartan-d2 is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
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Telmisartan-d4
0 ImagesCat. No.: HY-13955S1Synonyms: BIBR 277-d4Telmisartan-d4 is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
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SC-51316
0 ImagesCat. No.: HY-120776CAS No.: 133690-62-7SC-51316 is an oral active angiotensin II receptor antagonist with the IC50 values of 3.6 and 5.1 nM in rat adrenal cortical and rat uterine membrane, respectively. SC-51316 shows antihypertensive activity in vivo and in vitro.
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Arg-Glu(edans)-Ile-His-Pro-Phe-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Arg
0 ImagesCat. No.: HY-P5123Arg-Glu(edans)-Ile-His-Pro-Phe-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Ar is a fluorogenic renin substrate based on the N-terminal tetradecapeptide sequence of human angiotensinogen (hTDP).
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Losartan-d9
0 ImagesCat. No.: HY-17512S4CAS No.: 1030937-18-8Synonyms: DuP-753-d9Losartan-d9 is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
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Azilsartan-d4
0 ImagesCat. No.: HY-14914S1CAS No.: 1794817-45-0Synonyms: TAK-536-d4Azilsartan-d4 is the deuterium labeled Azilsartan. Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research.
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AT2R-IN-1
0 ImagesCat. No.: HY-170687CAS No.: 2896132-06-0AT2R-IN-1 (A-174) is a AT2R inhibitor, used in the research of neuropathic pain.
